TSC1 or TSC2 mutations cause excessive activation of mTOR pathway, leading to the promotion of cell growth and proliferation that caused a wide variety of tumor cell growth in TSC, including renal angiomyolipoma (RAML), pulmonary lymphangioleiomyomatosis (PLAM), subependymal giant cell astrocytoma (SEGA) and facial angiofibroma (8). This evidence concerns the gene TSC2 and kidney angiomyolipoma.