In the TSC1 truncating mutation group and the control group, we find that some of the differentially expressed proteins have been reported to be associated with epilepsy, including NQO1 (26), MOCS2 (27), PRODH (28), DCX (29), UBA5 (30), SRP9 (31), ARFGEF2 (32), ATG12 (33), MTR (34), KCNA2 (35), ADAM23 (36), KCNAB2 (37), TSC1 (10), IDS (38), GTF2I (39), and so on. The gene discussed is UBA5; the disease is epilepsy.