NRG4 and obesity due to melanocortin 4 receptor deficiency: Since adipose tissue hypoxia is one of the first physiopathological changes in WAT in obesity and leads to HIF1α and nuclear factor-kappa B (NF-κB) activation (Sun et al., 2011), the role of NRG-4 in inducing vascularization, thereby preventing hypoxia, contributes to the maintenance of a healthy metabolic profile and absence of inflammation.