NRG4 and cardiovascular disorder: Plasma NRG-4 has been reported to be decreased in obese children (Wang R et al., 2019) and adults (Cai et al., 2016) and in patients newly diagnosed with type 2 diabetes mellitus (Yan et al., 2017, 2018) while it is inversely associated with subclinical cardiovascular disease in obese adults (Jiang et al., 2016) and with the severity of coronary artery disease (Tian et al., 2019).