Studies using NRG-4 null mice as well as adipose tissue-overexpressing NRG-4 mouse models demonstrated that NRG-4 protects against HFD-induced insulin resistance by attenuating hepatic de novo lipogenesis (Wang et al., 2014; Ma et al., 2016) and activating mitochondrial fatty acid oxidation and ketogenesis (Chen et al., 2017). Here, NRG4 is linked to Insulin resistance.