FBXO32 and Cachexia: Moreover, using the pharmacological drug JQ1, a small molecule that suppresses Twist1 activity by blunting its binding to MuRF1 and Atrogin1 promoters, muscle cachexia could be reversed in PDAC mice deleted of Twist1, indicating that inhibition of Twist1 activity in muscle in indispensable for preventing muscle cachexia.