In the present study, to test whether lncRNA6406 could exert a significant effect on LPS-induced AKI by modulating the PTEN pathway, LPS-induced AKI was exacerbated by PTEN knockdown via transfection of PTEN siRNA, and then lncRNA 6406 was administered to assess its interaction with PTEN in the pathogenesis of AKI. The gene discussed is PTEN; the disease is acute kidney injury.