NGF and early-onset autosomal dominant Alzheimer disease: It has been proposed that alterations in the enzymatic pathway that controls the maturation of pro-nerve growth factor (NGF) to NGF and its subsequent degradation could be relevant in neurodegenerative processes such as Alzheimer’s disease that affect the activity of basal cholinergic neurons of the forebrain (Fahnestock and Shekari, 2019; Mitra et al., 2019; Mufson et al., 2019).