Performing microinjection of Klk6 protein into the dorsal column white matter of PAR-1 wild type and PAR-1 knockout mice, Burda et al. (2013) reported that PAR-1 promotes vacuolating myelopathy and loss of myelin basic protein, suggesting that KLK6 may regulate key biological and pathophysiological aspects of oligodendrocytes. The gene discussed is KLK6; the disease is Myelopathy.