Besides all the information referring to KLK6 and KLK8, such as their aberrant expression in Alzheimer’s disease and dementia (Ashby et al., 2010), a recent study expanded the KLKs contribution in CNS disorders by showing that the brain of Alzheimer’s disease patients presents decreased KLK7 mRNA expression. This evidence concerns the gene KLK7 and early-onset autosomal dominant Alzheimer disease.