MAPT and Alzheimer disease: Consequently, the use of iPSC-derived neurons in 3D cell cultures has been implemented to obtain and employ cells with a specific genetic background of AD patients in a system of higher similarity to the medium in vivo that provides a local environment brain tissue-like that promotes AD-like phenotypes such as elevated Aβ production and tau hyperphosphorylation, its aggregation, and accumulation (D’Avanzo et al., 2015; Raja et al., 2016; Gonzalez et al., 2018; Logan et al., 2019; de Leeuw and Tackenberg, 2019).