There is a strong correlation between fALS and the mutant RNA processing protein, including Cu/Zn superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP-43), C9ORF72(C9), and fused in sarcoma (Ince et al., 2011; Taylor et al., 2016; Starr and Sattler, 2018; Genevini et al., 2019; Yamawaki et al., 2019). This evidence concerns the gene TARDBP and sarcoma.