PRKN and Parkinson disease: PINK1 and Parkin have been shown to coordinate the selective clearance of damaged mitochondria via mitophagy (Matsuda et al., 2010; Vives-Bauza et al., 2010), and in recent years, there has been a large of amount of literature highlighting the mechanistic link between mitophagy deficiency and PD pathogenesis using cell culture models (Narendra and Youle, 2011; Youle and Narendra, 2011; Pickrell and Youle, 2015; Mouton-Liger et al., 2017; Truban et al., 2017; Miller and Muqit, 2019).