PRKN and Parkinson disease: Parkinson’s disease susceptible genes, which encode for proteins such as leucine-rich repeat kinase 2 (LRRK2), Parkin, PINK1, and DJ-1, are localized on the mitochondria and interfere with the function of mitochondria (Klein and Westenberger, 2012; Karimi-Moghadam et al., 2018).