Using various cellular markers, we evaluated the architecture of Tulp1-/- retinas compared to retinas from Rho-/- (Humphries et al., 1997) and retinal degeneration slow (Rds-/-) (Sanyal et al., 1980) mice, where retinal degeneration is believed to originate from photoreceptors. This evidence concerns the gene RHO and retinal degeneration.