In summary, the robust associations between KTN1 variants and PD, the replicable associations between KTN1 variants and putamen GMVs, the potential regulatory effects of KTN1 variants on the mRNA expression in putamen and SNc and the activities of lncRNA and enhancer, the abundant KTN1 mRNA expression in putamen and SNc, the differential mRNA expression in SNc between PD patients and controls, and the reported associations between putamen GMVs and PD, suggested that KTN1 variants may underlie the putamen GMV and risk for PD. Here, KTN1 is linked to Parkinson disease.