Whilst these associations with clock genes have not been replicated in larger studies and meta-analyses (Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014; Pardiñas et al., 2018; Rees et al., 2019; Wang et al., 2019), these larger studies have implicated SNPs in genes with a role in dopaminergic/glutamatergic neurotransmission, mitochondrial function and immunity. This evidence concerns the gene CLOCK and schizophrenia.