While HDAC6/α-synuclein PLA signal was undetectable or scarce in neuromelanin-containing cell bodies in control brains (Figures 4A,A’,C), it showed a scattered profile in the neuropil and a significantly increased punctate staining within neuronal cell bodies in PD brain (Figures 4B,B’,C). Here, HDAC6 is linked to Parkinson disease.