HDAC6 and Parkinson disease: We evaluated the expression of α-synuclein, phospho-HDAC6, and the motor protein dynein in control (Supplementary Figure S3A–A”’) and PD (Supplementary Figure S3B–B”’) brains and found that phospho-HDAC6 colocalization with α-synuclein and dynein significantly increased in PD patients (Supplementary Figure S3C), thus suggesting trafficking alterations.