Another interesting point linking α-synuclein to tau is that mutations in the SNCA and MAPT genes can both lead to neurodegenerative disorders characterized by parkinsonism (Polymeropoulos et al., 1997; Dumanchin et al., 1998; Spillantini et al., 1998; Fujioka et al., 2014). This evidence concerns the gene MAPT and Parkinson disease.