Recent publications reported that circular RNA (circRNA)-microRNA (miRNA)-mRNA networks were closely associated with cancer progression [37, 38] and drug resistance [14] in NSCLC, and this study identified a novel circRNA CDR1as/miR-641/HOXA9 pathway played an important role in the regulation of DDP chemoresistance in NSCLC. This evidence concerns the gene HOXA9 and cancer.