Specifically, the dual-luciferase reporter gene system results showed that miR-641 could bind to both circRNA CDR1as (Fig. 2b) and 3′UTR regions of HOXA9 mRNA (Fig. 2e) in HEK-293T cells, and the RNA pull-down assay validated that miR-641 could be enriched by both circRNA CDR1as (Fig. 2c) and HOXA9 (Fig. 2f) probes in NSCLC cells. This evidence concerns the gene HOXA9 and non-small cell lung carcinoma.