Similarly, further experiments validated that knock-down of circRNA CDR1as inhibited stemness properties in DDP-resistant NSCLC cells, and the inhibiting effects of circRNA CDR1as ablation on stemness in DDP-resistant NSCLC cells were abrogated by knocking down miR-641 and overexpressing HOXA9 (Fig. 5i–k), implying that circRNA CDR1as regulated stemness in NSCLC cells by targeting miR-641/HOXA9 axis in vitro. Here, HOXA9 is linked to non-small cell lung carcinoma.