The data related to the TDE roles in CRC are limited but it was approved that TDE in other cancers promotes invasiveness by regulating signaling pathway, for example, primary TDEs enhance SMAD3/ROS signaling and induce CTC survival and cell adhesion. Furthermore, the levels of TDEs markers which participated in EMT process cellular movement and cell–cell signaling in cancer patients’ blood correlated with the disease stage [3]. Here, SMAD3 is linked to cancer.