The analysis of two breast cancer cell lines, MDA-MB-231 and MCF-7, reveals RID's inhibitory capacity of the TNF-α-induced signaling pathway that activates NF-κβ and IL-8 secretion to the extracellular medium and by the reduction of neovascular processes in endothelial cells HMEC1 in culture. The gene discussed is TNF; the disease is breast cancer.