For both cohorts, the ICGS algorithm unbiasedly identified guide gene modules enriched for human stem and progenitor cells (HSPCs, CD34+), myeloid cells and thymocytes (Supplementary Fig. S3A and C and Supplementary Table S5), and ordered the T-ALL samples in clusters along a continuum of expression of these genes. Here, CD34 is linked to acute lymphoblastic leukemia.