For example, Cluster 1 was enriched both for T-ALL type NOTCH pathway-activating mutations (p < 0.0001, all comparisons by Fisher test) and for mutations that are more frequent in immature T-ALLs [9, 10, 40], e.g., SUZ12 (p = 0.004), WT1 (p = 0.0044) and IL7R/JAK/STAT pathway members (p = 0.0364). The gene discussed is SUZ12; the disease is acute lymphoblastic leukemia.