Previous studies established that the employment of EGFR tyrosine-kinase inhibitors (EGFR-TKIs) (such as gefitinib, erlotinib and ectinib) have achieved encouraging progress in treating NSCLC harboring EGFR mutations, unfortunately, NSCLC patients would inevitably become drug resistant27–31. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.