Although previous study illustrated that NOTCH-1 was conspicuously downregulated in LUAD cells and tumor tissues compared with normal cells and tissues5, former finding showed that NOTCH-1 exhibited elevated level in EGFR-mutant TKI-resistant NSCLC cells compared with the parental sensitive cells39, indicating the potential participation of NOTCH-1 in LUAD. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.