SELE and endothelial dysfunction: However, in mice on a HS diet, plasma E-selectin levels were significantly higher in eKO compared with wildtype mice at 4 weeks indicating possible endothelial dysfunction in eKO mice (Figure 4A, WT 1.47±0.14 ng/mL, eKO 2.15±0.19 ng/mL, P<0.05).