Interestingly, no correlation was observed between FTO (rs1121980) DNA methylation and BMI as this locus was hypomethylated in obese and non-obese T2DM patients compared with controls, suggesting that the association between FTO (rs1121980) DNA methylation and T2DM may not be mediated through obesity. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.