The majority of T2DM DMRs were identified in loci with known functions in pancreatic islets, including ADCY5, PDX-1, and TCF7L2. In addition, the study identified 457 genes with DMRs representing significant changes in the gene expression in T2DM islets, including SLC2A2, PARK2, SOCS2, NR4A3, and PID1 [95]. This evidence concerns the gene PRKN and type 2 diabetes mellitus.