Moreover, some of the differentially methylated T2DM-associated CpG-SNP sites were found to be associated with hormone secretion in the human islets, where CpG-SNPs in ADCY5 (rs11708067) and KCNQ1 (rs2237895) were associated with glucagon secretion, whereas those of ADCY5 (rs11708067) and HHEx (rs5015480) were associated with insulin secretion, and that of CDKN2A (rs564398) was associated with insulin content. This evidence concerns the gene INS and type 2 diabetes mellitus.