Interestingly, the study associated a specific GRB10 variant, namely, the A-allele of rs933360, with decreased insulin sensitivity, non-affected GSIS, increased fasting plasma glucose level and increased risk of T2DM if inherited from the father and an enhanced insulin sensitivity, reduced GSIS, and reduced fasting plasma glucose level if inherited from the mother. This evidence concerns the gene INS and type 2 diabetes mellitus.