Interestingly, the study associated a specific GRB10 variant, namely, the A-allele of rs933360, with decreased insulin sensitivity, non-affected GSIS, increased fasting plasma glucose level and increased risk of T2DM if inherited from the father and an enhanced insulin sensitivity, reduced GSIS, and reduced fasting plasma glucose level if inherited from the mother. The gene discussed is GRB10; the disease is type 2 diabetes mellitus.