Furthermore, epithelial-mesenchymal transition (EMT)—specific transcription factor ZEB1 protein can directly inhibit the mRNA level of epithelial splicing regulatory protein 1 (ESRP1), which leads to the increased expression of various spliceosomes of cell surface antigen CD44 and induces lung, breast, and pancreatic cancer stem-like and aggressive cells [35–37]. The gene discussed is ESRP1; the disease is familial pancreatic carcinoma.