Second, CD86+ cells were significantly increased, while CD163+ cells were significantly decreased in THP-1 macrophages co-cultured with overexpressed CPEB3 CRC cells, which showed significantly higher expression of IL-1β, TNF-α, IL23, IP10, and IL-12p70, illustrating a predominantly M1 phenotype. Here, CPEB3 is linked to colorectal carcinoma.