TNF and colorectal carcinoma: To determine how CPEB3 in CRC cells regulates TAM polarization via IL-6R/STAT3 signaling, we used Luminex assays to screen for major cytokines, which may induce TAM differentiation in the culture supernatants of stably transfected CRC cells, including IFN-γ, IL-1β, IL-1RA, IL-4, IL-6, IL-10, IL-12p70, IL23, IP10, TNF-α, and CCL2.