Prominent biological abnormalities consisted of KDIGO stage 3 AKI (Blood urea: 30 mmol/L plasma creatinine: 497 μmol/L) and hematological thrombotic microangiopathy (TMA) (hemoglobin levels: 13.1 g/dL, platelets: 47000 / mm3, haptoglobin levels < 0.20 g/dl, greatly elevated LDH levels: 1843 UI/L and schistocytes were detected). This evidence concerns the gene HP and thrombotic microangiopathy.