The question arose of whether there was a relationship between insulin sensitivity and myostatin expression, in part because the current data differed from previous studies in T2D where muscle myostatin mRNA and/or protein is elevated in the diabetic state (Brandt et al., 2012; Hittel, Berggren, Shearer, Boyle, & Houmard, 2009). The gene discussed is MSTN; the disease is type 2 diabetes mellitus.