Interestingly, neither serum nor muscle myostatin expression was related to HbA1c (Figures 1h and 2f,i) lending support for a potential role of myostatin in the development of insulin resistance, as previously suggested (Amor et al., 2018; Brandt et al., 2012; Hittel et al., 2009), that is distinct from its effects on systemic glycemic control as measured by HbA1c. The gene discussed is MSTN; the disease is Insulin resistance.