This study advances the field by demonstrating that (a) SLE mice treated with curcumin are able to preserve their body weight, (b) spleen weight is lower in SLE mice treated with curcumin until 28 weeks of age, but not does affect circulating CD45R+ B cells or anti‐dsDNA IgG autoantibodies, (c) curcumin treatment attenuates glomerulosclerosis but does not affect albuminuria, and (d) curcumin, at the dose and duration in this study, does not alter systemic or renal hemodynamic function in female NZBWF1 SLE mice. This evidence concerns the gene PTPRC and systemic lupus erythematosus.