With the continuous promotion of stroke care and prevention, the standardized mortality rate shows a downward trend in China (Wang, Hu, Sang, Luo, & Yu, 2017), while there is a significant upward trend for disability‐adjusted life years (DALY; Report on Stroke Prevention & Treatment in China, 2018) Early reperfusion therapy, including intravenous recombinant tissue plasminogen activator (rt‐PA) thrombolysis within 4.5 hr and mechanical thrombectomy (MT) within six hours of symptom onset, is the most effective evidence‐based treatment for acute ischemic stroke (AIS; Powers et al., 2018). This evidence concerns the gene PLAT and Stroke.