The following models were found to be associated with the PD, both allele and additive model of the rs8180209 of SNCA (allele model: P = .047, OR = 0.77; additive model: P = .047, OR = 0.77); the dominant model of the rs2270968 of MCCC1, with (P = .023, OR = 1.52) or without (P = .024, OR = 1.52) adjusting the age and gender; and the recessive model of the rs7479949 of DLG2 (P = .019, OR = 0.26). The gene discussed is DLG2; the disease is Parkinson disease.