Despite their well‐known survival benefits in HF patients, there is no clear guidance on the use of beta‐blockers, angiotensin‐converting enzyme inhibitors (ACEis), angiotensin‐receptor blockers (ARBs) and mineralo‐corticoid receptor antagonists (MRAs) in CKD–HF patients due to exclusion of severe CKD patients from major clinical trials.1 Here, NR3C2 is linked to hydrops fetalis.