BACE1 and Cognitive impairment: Altogether, the results from our study showed that one-month intragastric administration of CPPs attenuated cognitive impairments in APP/PS1 mice, and this effect was associated with reduced Aβ levels in the hippocampus and reduced BACE1 activity, indicating that the beneficial effects of CPPs treatment might be mediated through the suppression of BACE1 activity.