MITF and melanoma: In melanocytes and melanoma, MITF is the transcriptional regulator of V-ATPase gene expression (Bouché et al., 2016; Zhang et al., 2015), and these genes are required for autophagosome formation in response to starvation (Möller et al., 2019) and are also required for endolysosomal vesicles that function as concentrating centers for Wnt signaling (Ploper et al., 2015).