In addition, the CD8+ T-cell subsets, including CD8+ T cells in general as well as Tc cells, MAIT cells, and Tex cells, were significantly correlated with the CD4+ T-cell subsets in normal pituitaries, and these correlations were attenuated in corticotroph adenomas, somatotroph adenomas, and NFPAs but amplified in gonadotroph and lactotroph PAs. Here, CD8A is linked to ACTH-producing pituitary gland adenoma.