In fact, ACE2 and TMPRSS2 exhibit high mRNA expression in thethyroid in both sexes (Fig. 1); the first case ofsubacute thyroiditis (a thyroid dysfunction due to a viral infection or a postviralinflammation of the thyroid) associated with SARS-CoV-2 infection was reported in a youngItalian woman (71). Here, ACE2 is linked to thyroid gland disorder.