Different types of HLA complexes such as HLA-DQ2.5 (HLA-DQA1*05/HLA-DQB1*02), HLA-DQ8 (HLA-DQA1*03/HLA-DQB1*03:02), and HLADQ2.2 (HLA-DQA1*02:01/HLA-DQB1*02) are associated with coeliac disease pathogenesis [28, 29] and have been reported in more than 90% of coeliac disease patients [30]. This evidence concerns the gene HLA-DQA1 and celiac disease.