Moreover, amiodarone-treated patients revealed mean serum levels of caspase-cleaved K18 > 200 U/L, a cut-off value which was closely related to the presence of non-alcoholic steatohepatitis (NASH) and fibrosis in NAFLD studies (Liebig et al. 2019; Feldstein et al. 2009). This evidence concerns the gene KRT18 and metabolic dysfunction-associated steatotic liver disease.