RUNX3 and neoplasm: We found that both endogenously and exogenously expressed β-catenin (desmoid tumor cells and 293T transfected cells, respectively) coimmunoprecipitated with RUNX3 in desmoid cell lines (Fig. 5d) and 293T cells (Fig. 5e), suggesting that the type of mutation has no effect on the β-catenin binding to RUNX3.