In further agreement, our data also suggests that differential plastic response to OSA in the brain may depend on regional genes expressional profiles39 For example our ‘MR-gene’ mapping findings support permissive and cohesive role for the TLR2-system in the interplay with BDNF, RSGRP1, fibronectin and neuroplastin-driven significant discrete and transformative neurophysiologic and behavioural changes. This evidence concerns the gene TLR2 and obstructive sleep apnea syndrome.