Therefore, we searched the PDB database for the 3D structures of the 13 potential targets of YZHG in the treatment of hepatitis B and found 3D structures for 10 of the targets (CDK2, GPT, EHMT2, STAT3, JUN, BRCA1, TP53, TNF, CREB, and CDK6); the 3D structures of NOD2 and CCNB2 were not available, and the 3D structure of TLR9 did not have a human source. The gene discussed is NOD2; the disease is hepatitis B virus infection.