CDK4 and chronic hepatitis: The analysis of Module 1 revealed that CDK1 and CDK4, in addition to CDK6, also belong to the CDK family, which indicates that they might be responsible for the synergistic effects of YZHG on the treatment of hepatitis B. For example, the study suggests that CDK4 is involved not only in the process from a normal liver to chronic hepatitis but also during the transition to HCC45.