APP and Alzheimer disease: In the present study, we worked with 5XFAD mice, a transgenic mouse model of AD that overexpresses mutant human amyloid beta precursor protein (APP695) with the Swedish (K670N, M671L), Florida (I716V), and London (V717I) familial Alzheimer's disease (FAD) mutations, along with human PS1 harboring 2 FAD mutations, M146L and L286V.