IDH1 and central nervous system cancer: We found that IDH1 (R132H) mutant gliomas had a mean score of 1.31 ± 0.31 (SEM) while IDH1 wild-type gliomas had a mean score of 2.36 ± 0.21 (SEM), significantly differing with a two-tailed P value of 0.0063 (Supplementary Fig. 3j).