MYC was first discovered to enhance fatty acid synthesis in rat fibroblasts, and multiple follow-up studies confirmed this regulation in prostate cancers, MYC-driven lymphoma tumors, MYC-driven hepatocellular carcinomas, and renal cell carcinomas.5,54–57 MYC promotes citrate production, which is the precursor of de novo fatty acid synthesis, through upregulation of a series of genes involved in TCA cycle driven from glucose and glutamine metabolism. This evidence concerns the gene MYC and hereditary clear cell renal cell carcinoma.