In addition to MYC, HIF-2α, the Hippo pathway effectors, the hormone receptors, and the stress response factor ATF4 were shown to upregulate SLC7A5 and/or SLC43A1 expression in multiple cancer types, including clear cell renal carcinoma, hepatocellular carcinoma, breast and prostate cancers,36–40 which leads to elevated EAA uptake and aggressive tumor progression. This evidence concerns the gene SLC7A5 and cancer.