Both MYC and MYCN collaborate with HIF-1α to stimulate the expression of key glycolytic genes in response to hypoxia, such as HK2 and pyruvate dehydrogenase kinase 1 (PDK1) in MYC-driven Burkitt’s lymphoma cells, and LDHA in MYCN-amplified neuroblastoma cells, suggesting cooperation between MYC oncoproteins and HIF-1α plays an important role in regulation of glucose metabolism in cancers.24,25. This evidence concerns the gene HK2 and cancer.