The Mondo transcription factor MondoA represents a nutrient-sensing branch of this network.94 Since MYC drives the uptake of glucose by competing with MondoA and inhibiting TXNIP expression, one could speculate that the increased degradation of MYC upon glucose deprivation could positively regulate MondoA-TXNIP axis, thus contributing to maintain the cancer cells in a metabolically inactive state.95 This evidence concerns the gene TXNIP and cancer.