Members of the SLC7 family (SLC7A5 and SLC7A8), the SLC43 family (SLC43A1 and SLC43A2), the SLC6 family (SLC6A14), and the SLC38 family (SLC38A1–SLC38A11) primarily mediate the uptake of EAAs.29 We recently identified a MYC-SLC7A5/SLC43A1 signaling circuit that underlies LNEAA metabolism, MYC deregulation, mTOR complex 1 (mTORC1) activation, and tumor progression. Here, SLC7A5 is linked to neoplasm.