MYC and colorectal cancer: Dejure and colleagues recently show that, in colorectal cancer cells, translation of MYC is controlled by glutamine via a sequence element within the 3′-UTR of MYC mRNA.90 Surprisingly, this regulatory sequence does not respond to TCA cycle intermediates, but to intracellular levels of glutamine-derived adenosine nucleotides.90 The precise mechanisms whereby adenosine levels regulate MYC translation upon glutamine deprivation remain to be resolved.