NF1 and neoplasm: In the p53m/m, nf1b−/−, nf1a+/+ or nf1a−/+ backgrounds, we observed a strong diversification of tumorigenesis upon loss of the important epigenetic regulator tumor suppressor suz12. By contrast, loss of the Ras-inactivating tumor suppressor nf1 in suz12-wild-type fish mainly accelerated the onset of MPNSTs, while inducing none of the other neoplasms observed in our study (Shin et al., 2012).