NF1 and neoplasm: Moreover, SUZ12 loss can elevate expression of Hox genes such as HOXC13 (Marcinkiewicz and Gudas, 2014), which is implicated in metastatic dissemination in melanoma (Cantile et al., 2012), another tumor in which SUZ12 LOF often cooperates with NF1 loss (De Raedt et al., 2014).