TP53 and soft tissue sarcoma: In the p53/nf1/suz12-mutant line, we observed MPNSTs as well as leukemias with histological characteristics of lymphoid malignancies, pancreatic adenocarcinoma, a soft tissue sarcoma in the head region, and one case of a mixed mesenchymal/epithelioid tumor in the tail that was not further definable and therefore was referred to as adenosarcoma (Fig. 1C, Table S2).