It is known that the combined deficiencies in p53 and nf1 synergize in the onset of MPNSTs and high-grade gliomas (Shin et al., 2012), and that the combined deficiencies in Suz12 and Nf1 cooperate in widespread tumor development in mice (De Raedt et al., 2014). The gene discussed is NF1; the disease is central nervous system cancer.