In mice, it is known that combined deficiencies in Tp53 and Nf1 synergize in the onset of MPNSTs and high-grade gliomas, and that the combined loss of Suz12 and Nf1 cooperate in the initiation of MPNSTs without loss of Tp53 (De Raedt et al., 2014). Here, NF1 is linked to glioma.