NFIB and neoplasm: We observed that MEK inhibition resulted in a decreased tumor size for both p53m/m, nf1b−/−, nf1a+/−, suz12-mutant MPNSTs and p53m/m,nf1b−/−, nf1a+/−, suz12-wild-type MPNSTs (Fig. 5B,C).