SUZ12 is reported to be a tumor suppressor gene in malignant peripheral nerve sheath tumors (MPNSTs) and high-grade gliomas (HGGs) (De Raedt et al., 2014; Lee et al., 2014), while in epithelial ovarian cancer, breast cancer and other malignancies (Li et al., 2012; Kirmizis et al., 2003), it might function to promote oncogenesis. This evidence concerns the gene SUZ12 and central nervous system cancer.