Although lncRNA HOTAIR, one of the most studied long non-coding RNAs, is reported to be elevated in patients with metastasis and poor prognosis in many cancer types, analysis of HOTAIR in TCGA datasets revealed that HOTAIR has a context-dependent expression pattern which is not always upregulated through the progression of the disease (Fig. 8d-e). The gene discussed is HOTAIR; the disease is cancer.