NR1H4 and esophageal adenocarcinoma: Regarding to cancer, a loss of FXR expression has been associated with tumorigenic phenotypes in the liver, intestine and colon, where FXR has an antitumor function [22, 23], while its overexpression may also induce non-small cell lung cancer (NSCLC) and esophageal adenocarcinoma [15, 16].