VDR and nephrolithiasis: However, our most recent update meta-analysis in 2020, by including 33 studies (a total of 2950 cases/3065 controls for ApaI polymorphism, 3065 cases/ 2915 controls for BsmI polymorphism, 3114 cases/3174 controls for FokI polymorphism, and 4188 cases/3955 controls for TaqI polymorphism), indicated that none of the VDR gene polymorphisms mentioned above were associated significantly with nephrolithiasis risk in the overall analysis except ApaI SNP.