Moreover, the blood DML detected in comparing those with 10+ years of plantation work exposure to 0 years identified ‘neurological disorders’, e.g., movement disorders, neuromuscular disease, and Parkinson’s disease as top pathways (Additional file 3: Figure S1) The most important genes among the 15 genes with DML in these pathways are Androgen Induced 1 (AIG1), glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A), B-Cell CLL/Lymphoma 2 (BCL2), Serum/Glucocorticoid Regulated Kinase 1 (SGK1), and microtubule associated protein gene (MAPT). Here, GRIN2A is linked to neuromuscular disease.