Since many neurodegenerative diseases, such as Parkinson’s disease, involve the accumulation of aberrant and damaged proteins, e.g., a-synuclein and Lewy bodies, and since the Ubiquitin Proteasome System (UPS) is crucial for the degradation of these proteins and hence maintenance of protein homeostasis and normal cell function, reactive gliosis which affects the efficiency of the UPS [72], by promoting proteasome inhibition and neuroinflammation [73], plays a critical role in these diseases. Here, SNCA is linked to neurodegenerative disease.