Interestingly, after intratracheal instillation of lipopolysaccharides from P. aeruginosa to promote lung inflammation (n = 3), a significant increase in the HspB5 level was observed in (+/+) mice (2.57 ± 0.47 ng/μg of proteins), whereas no significant change was observed in F508del/F508del mice (2.96 ± 0.41 ng/μg of proteins) (Figure 1B). This evidence concerns the gene CRYAB and inflammation.