NFKB1 and viral infectious disease: OTUD4 is induced by virus infection and targets MAVS ubiquitination, triggeringIRF3 and NF-κB signaling to sustain antiviral responses [85].Like most of the DUBs, the family member A20 shows the negative effect on the activation of NF-κB signaling [87,88,133].Myeloid-A20-deficiency shows a higher inflammatory reaction and sustained NF-κB activation [133].