E2F1 and Hepatic fibrosis: Among six potential transcription factors (conserved between mice and humans) that bind at the proximal promoter region of the identified BCL2 gene (Supplementary Table S4), we focused on c-MYC as it is known to modulate liver fibrosis [53] and is regulated by miR-122 through E2F1 and TFDP2 in mouse hepatic cells [37].