HMOX1 and colitis: NED treatment also increased HO-1 mRNA (p < 0.05 at 100 mM and p < 0.01 at 150 mM) (Figure 6g) and SOD3 mRNA expression significantly (p < 0.05 at 100 mM and p < 0.01 at 150 mM) in DSS colitis colon (Figure 6g).