NFKB1 and type 1 diabetes mellitus: T1D is associated with over 60 genetic risk regions across the human genome, identified by genome-wide association studies (GWAS) [124], and these T1D-linked SNPs alter the expression of over 200 genes [125] involved in β-cell inflammation, function and destruction, immune activation and signaling, including viral response, Toll-like receptor, cytokines and NF-κB signaling.