We focused also on hepatic glycogenesis and gluconeogenesis pathways, as well as on the secretion profile of several hormones and mediators involved in the control of the insulin-glucose metabolic homeostasis axis: leptin (whose signaling deficiency produces diabetes type 2), adiponectin (an insulin sensitizer), or ghrelin (that inhibits insulin release from pancreatic islets) [1,20,21,22]. Here, INS is linked to type 2 diabetes mellitus.