SP1 and hepatocellular carcinoma: In addition, the expression of SP1 (Figure 4C, left and middle panel, p < 0.001), the transcription factor controlling ectopic TIAM2S expression in hepatocellular carcinoma [10], is highly correlated with the TIAM2S protein in these CRC cell lines (Figure 4D, r = 0.508, p < 0.05).