Furthermore, while WT mice were unable to develop colon cancer under AOM treatment due to colon cancer susceptibility locus 3 (Ccs3) resistance in the C57B6/JNarl strain background [25], the carcinogen alone effectively induced development of colonic adenoma in TG mice starting at 22 weeks after AOM treatment. The gene discussed is EEF1A1; the disease is malignant colon neoplasm.